Journal of Yeungnam Medical Science

Yun Woo Cho

2 Articles

Transcallosal Fibers from the Corticospinal Tract in Adults with Brain Injury: Sung Ho Jang, Sang Ho Ahn, Yun Woo Cho; Yeungnam Univ J Med. 2007;24(2 Suppl):S424-429. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S424

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Background
：Diffusion tensor image tractography (DTT) can visualize white matter tracts and provide us with a powerful vehicle for investigating the neuralpathway at the subcortical level. Using DTT, we attempted to demonstrate abnormal transcallosal fibers from the corticospinal tract in patients with brain injury. Materials and Methods：Four adults with brain injury (2 patients: stroke, 1 patient: brain tumor with hemorrhage, 1 patient: diffuse axonal injury) and 14 normal control subjects were enrolled in this study. DTT was performed using 1.5-T with a Synergy-L Sensitivity Encoding head coil. Three-dimensional reconstructions of the fiber tracts were obtained with FA<3.0, and an angle change >45o as termination criteria.
Results
：Transcallosal fibers were observed in two of 14 normal controls, and ascended to the cortex leaving the corpus callosum. All four patients showed transcallosal fibers which stemmed from the corticospinal tract of the unaffected hemisphere, and descended to or around the lesion at the subcortical area.
Conclusion
：It seems that transcallosal fibers which arise from the corticospinal tract of the unaffected hemisphere may act as pathological fibers for motor deficit compensation.

Citations

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Usefulness of DTI-based three dimensional corticospinal tractography in children with hemiplegic cerebral palsy
Ji Hyun Yeo, Su Min Son, Eun Sil Lee, Han Ku Moon
Korean Journal of Pediatrics.2009; 52(1): 99. CrossRef

The Effect of Gabapentin for the Clinical Symptoms in the Traumatic Neuropathic Pain.: Yeung Ki Kim, Yun Woo Cho; Yeungnam Univ J Med. 2004;21(1):82-90. Published online June 30, 2004; DOI: https://doi.org/10.12701/yujm.2004.21.1.82

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Abstract PDF: BACKGROUND
Gabapentin is widely used for the relief of neuropathic pain. But, there is no study of gabapentin in relation to traumatic neuropathic pain. The aim of this study is to assess the efficacy and effectiveness of gabapentin for the various clinical symptoms of traumatic neuropathic pain MATERIALS AND METHODS: 50 patients with traumatic nerve injury were assigned to receive gabapentin, titrated to 900 mg/day over 9 days, followed by further increases to a maximum of 2400 mg/day. Continuous pain, paroxysmal pain, allodynia and thermal evoked pain were measured in mean daily pain scores, based on the 11-point Likert scale. The primary efficacy parameter was compared from the baseline to the final study week. RESULTS: Over the 4.5 week study, this pain score decreased by 2.6 points in the continuous pain, 3.6 points in the paroxysmal pain, 3.1 points in the allodynia, and 2.5 points in the thermal evoked pain. The percentage of patients with over 50% improvement in pain scores was 33% in the continuous pain, 67% in the paroxysmal pain, 53% in the allodynia and 36% in the thermal evoked pain. There was no significant correlation between the effect of gabapentin and the time difference of the onset of symptoms and start of medication. CONCLUSIONS: This study shows that gabapentin reduced neuropathic pain in patients with traumatic peripheral nerve injury. Among the various characteristics of neuropathic pain, the reduction of paroxysmal pain and allodynia was greatest.

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